Contribution at HIV Research for Prevention 2014 (Cape Town, 28-31 October)

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The contribution was accepted for poster presentation at HIV Research for Prevention 2014 (Cape Town, 28-31 October). iHIVARNA reported the in vitro results of the immunogenicity assays performed with different mRNA combination sequences: HIVACAT mRNA sequence and TriMix mRNA sequences.

In summary mRNA Electroporation of DCs (HIVACAT+Trimix) improved their maturation status and was able to enhance HIV specific T cells responses. Taking advantages of these features, directly administration to the patient without the need to modify DCs ex vivo, suggest that this mRNA combination should be useful in HIV therapeutic vaccine approaches.

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