The four-year 6M€ European project iHIVARNA, funded by the European Commission, aims to successfully immunize antiretroviral-treated HIV-infected patients with 3 injections of the candidate universal HIV-TriMix-mRNA as an mRNA-based therapeutic vaccine with the final aim of improving the efficacy of therapeutic vaccination against HIV infection. The final objective of the project is to generate knowledge for reaching the functional cure of HIV infected patients.

The project brings together the expertise of a number of European groups (Spain, Belgium, and Netherlands) in a number of fields required for an adequate development of the therapeutic vaccine (dendritic cell targeting, rational design of immunogens, mRNA manufacturing and immuno-virological monitoring).